Arun Cumpelik, MD PhD

Arun Cumpelik, MD PhD

Hometown: Prague
Medical School: 1st Faculty of Medicine Charles University
Residency: Mount Auburn Hospital
Research/Academic Interests: Transplant immunology, Complement research, Germinal B-cell biology
Bio: Amateur baker, newly minted dad, cycling enthusiast.

Selected Publications/Abstracts

  • Cumpelik A et al. Erythrocyte-derived microvesicles amplify systemic inflammation by thrombin-dependent activation of complement. Arteriosclerosis, Thrombosis and Vascular biology. 2014 Feb;34(2):313-20. PubMed PMID: 24311376.
  • Cumpelik A et al. Mechanism of Platelet Activation and Hypercoagulability by Antithymocyte Globulins (ATG). American Journal of Transplantation. 2015 Oct;15(10):2588-601. PubMed PMID: 25966640.
  • Cumpelik A et al. Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome. Annals of the Rheumatic Diseases. 2016 Jun;75(6):1236-45. PubMed PMID: 26245757.
  • Cumpelik A et al. Human nanovesicles in physiology and pathology, Nanotechnology for Human Health. Wiley. 2016.
  • Cumpelik A et al. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal of the American Society of Nephrology. 2018 Nov;29(11):2641-2657. PubMed PMID: 30341149.
  • Cumpelik A et al. Dynamic regulation of B-cell complement signaling is integral to germinal center responses. Nature Immunology. 2021 Jun;22(6):757-768. PubMed PMID: 34031614.
  • Cumpelik A et al. Erythropoietin reduces auto- and allo-antibodies by inhibiting T follicular helper cells differentiation. Journal of the American Society of Nephrology. 2021 Oct;32(10):2542-2560. PubMed PMID: 34261755.
  • Cumpelik A et al. AMP-Kinase mediates regulation of glomerular volume and podocyte survival. JCI Insight. 2021. 2021 Oct 8;6(19):e150004. PubMed PMID: 34473647.
  • Cumpelik A et al. Complement independent role for mannan binding lectin in murine graft versus host disease. Transplantation and cellular therapy. 2022 Aug;28(8):472.e1-472.e11. PubMed PMID: 35643350.
  • Cumpelik A et al. Effects of the complement system on antibody formation and function: implications for transplantation. Current Opinion in Organ Transplantation. 2022 Oct 1;27(5):399-404. PubMed PMID: 35857345.
  • Cumpelik A et al. Neutrophil Complement Receptor Signaling Is Required for BAFF-Dependent Humoral Responses in Mice. Journal of Immunology. 2023 Jan 1;210(1):19-23. PubMed PMID: 36454023.