Joshua Siner, MD

1st Year Fellow

Hometown: Mullica Hill, NJ
Medical School: Cooper Medical School of Rowan University; Camden, NJ
Residency: The Warren Alpert Medical School of Brown University / Rhode Island Hospital
Research/Academic Interests: Classical Hematology
Bio: I’m a new transplant to St Louis after having spent my life and training between Philadelphia, New Jersey and most recently in Rhode Island. My out of hospital interests have included an over attachment to the Philadelphia 76ers basketball team and looking forward exploring the regional craft beer, completely unrelated. I’m looking forward to fall adventures through Forest Park.

Selected Publications/Abstracts

  • Siner JI, Samelson-Jones BJ, Crudele JM, French RA, Lee BJ, Zhou S, Merricks E, Raymer R, Nichols TC, Camire RM, Arruda VR.  Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.  JCI Insight.  2016 Oct b;1(16):e89371.
  • Nguyen GN, George LA, Siner JI, Davidson RJ, Zander CB, Zheng XL, Arruda VR, Camire RM, Sabatino DE. Novel factor VIII variants with a modified furin cleavage site improve efficacy of gene therapy for hemophilia A.  J Thromb Haemost. 2017 Jan;15(1):110-121.
  • Crudele JM, Finn JD, Siner JI, Martin NB, Niemeyer GP, Zhou S, Mingozzi F, Lothrop CD Jr, Arruda VR.  AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice.  Blood.  2015 Mar 5;125(10):1553-61.
  • Siner JI, Iacobelli NP, Sabatino DE, Ivanciu L, Zhou S, Poncz M, Camire RM, Arruda VR.  Minimal modification of the factor VIII B domain sequence ameliorates the murine hemophilia A phenotype. Blood.  2013 May 23;121(21):4396-403.
    Favaro P, Finn JD, Siner JI, Wright JF, High KA, Arruda VR.  Safety of liver gene transfer following peripheral intravascular delivery of adeno-associated virus (AAV)-5 and AAV-6 in a large animal model.  Hum Gene Ther. 2011 Jul;22(7):843-52.