Gregory Fox, MD, PhD

Gregory Fox, MD, PhD

Hometown: Rockwall, TX
Medical School: Washington University School of Medicine
Residency: Washington University in St. Louis/Barnes-Jewish Hospital
Research/Academic Interests: Solid tumors, tumor cell dissemination and metastasis, tumor metabolism, synthetic lethality
Bio: I moved to Saint Louis in 2013 for WashU’s Medical Scientist Training Program and absolutely fell in love with the institution and city, both of which are notable for their sense of collegiality, collaboration, and passion for fostering work with the potential for sustained, positive impact in the lives of others. I also have both Saint Louis and WashU to thank for my marriage: I met the woman who would become my wife after a chance encounter in the flow cytometry core while we were both graduate students, then again several weeks later at the local church we (each unbeknownst to the other) had attended for multiple years.

These days, my non-hospital life is full of renovation projects on our 100+ year-old fixer upper, exploring Saint Louis’s sneakily incredibly food scene, reading a good book with a glass of wine and my cats on our screened-in patio, and rewatching Ocean’s Eleven for the hundredth time.

Selected Publications/Abstracts

  • Su, X., Xu, Y., Fox, G.C. et al. (2021). Breast cancer derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment. J Clin Invest.
  • Fox, G. C. et al. (2021). Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases. Mol Cancer Ther. 20:1183-98.
  • Fontana, F., Xiang, J., Su, X., Tycksen, E., Nassau, R., Fox, G. et al. (2021). N-cadherin in osteolineage cells modulates stromal support of tumor growth. Journal of Bone Oncology. 28:100356.
  • Esser, A.K., Ross, M.H., Fontana, F., Su, X., Gabay, A., Fox, G.C. et al. (2020). Nanotherapy delivery of c-myc inhibitor targets protumor macrophages and preserves antitumor macrophages in breast cancer. Theranostics 10(17):7510.
  • Xiang, J., Rauch, D., Huey, D., Panfil, A., Cheng, X., Esser, A., Su, X., Harding, J., Xu, Y., Fox, G.C. et al. (2019). HTLV-1 viral oncogene HBZ drives bone destruction in adult T cell leukemia. JCI Insight 4(19).
  • Ross, M. H., Esser, A. K., Fox, G. C. et al. (2017). Bone-induced expression of integrin β3 enables targeted nanotherapy of breast cancer metastases. Cancer Res., 77(22), 6299-6312.
  • Su, X., Esser, A.K., Amend, S.R., Xiang, J., Xu, Y., Ross, M.H., Fox, G.C. et al. (2016). Antagonizing integrin β3 increases immunosuppression in cancer. Cancer Res. 76:3484–3495.